Gating currents indicate complex gating of voltage-gated proton channels
نویسندگان
چکیده
منابع مشابه
Taking Apart the Gating of Voltage-Gated K+ Channels
؉ Channels labeling studies of KcsA suggest that K ϩ channels may gate by rotating the inner helices that line the pore (Per-ozo et al., 1999). In this model, the degree of rotation of the helices regulates the aperture of the inner mouth of the pore that opens and closes like the shutters of a San Francisco, California 94143 camera. For voltage-gated K ϩ channels, this model is broadly consist...
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Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent neurotoxins. These channels are built on a common structural motif containing six transmembrane segments and a pore loop. Their pores are formed by the S5/S6 segments and the pore loop between them, an...
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A battle is raging over the molecular identity of the voltage-gated, H -selective conductance that has been recorded in activated and/or depolarized phagocytes. Having stepped out of this arena, we feel uncommitted to any particular viewpoint and hope to be able to provide below an unbiased opinion of what we feel has been established unambiguously, and what requires additional confirmation bef...
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Large-conductance Ca(2+)-activated K(+) channels can be activated by membrane voltage in the absence of Ca(2+) binding, indicating that these channels contain an intrinsic voltage sensor. The properties of this voltage sensor and its relationship to channel activation were examined by studying gating charge movement from mSlo Ca(2+)-activated K(+) channels in the virtual absence of Ca(2+) (<1 n...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1813013115